The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Prostate Cancer Susceptibility Loci

Added text about a study that suggests that BRCA2 mutation carriers have a poorer survival compared with BRCA1mutation carriers (cited Narod et al. as reference 120).

Cited Agalliu et al. as reference 148.

Added text to state that an association is similar to the 17q12 finding corroborated in hereditary prostate cancer and early-onset prostate cancer has been found in an African American population (cited Sun et al. as reference 149).

Polymorphisms and Prostate Cancer Susceptibility

Added subheadings throughout this section.

Added text about a study that demonstrated men with hereditary prostate cancer had a higher percentage of prostate cancer exhibiting the expression of the androgen receptor than men with sporadic prostate cancer (cited Fromont et al. as reference 11).

Added text about a meta-analysis that had similar findings of increased prostate cancer risk in carriers of the -160→A allele in the E-cadheringene when compared to a prior meta-analysis (cited Qiu as reference 37).

Added toll-like receptor genes as new subsection.

Interventions in Familial Prostate Cancer

Added text about a study that analyzed prostate cancer detection and the need to further define optimal screening measures in men with a family history of prostate cancer (cited Giri et al. as reference 15).

Added text about an analysis of data from the control arm of the PCPT that yielded a prostate cancer risk model that might predict the likelihood that a man undergoing biopsy would have prostate cancer (cited Thompson et al. as reference 16).

Psychosocial Issues in Prostate Cancer

Added healthy Australian males with no history of prostate cancer as a study population in Table 5 (cited Cowan et al. as reference 21).