Related terms: streptozocinchlorozotocinzanosarganumof-strep protocolfam-s protocol
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Influence of streptozotocin upon the induction of tyrosine aminotransferase, the content of NAD and of 5-methyl cytosine in rat liver.
The antibiotic, streptozotocin, has carcinostatic, carcinogenic, and diabetogenic properties. Moreover, it is capable of inducing the enzyme tyrosine aminotransferase in a permanent line of rat liver cells. In the present…
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Pancreatic islet cell carcinoma in a dog treated with streptozotocin.
After surgical removal of the primary tumor and recurrence of hypoglycemia, a dog with metastatic pancreatic islet cell carcinoma was treated with streptozotocin. Nephrotoxicosis resulted after a single administration of…
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Temporary remission of hypoglycemia in a dog with an insulinoma after treatment with streptozotocin.
Temporary remission of hypoglycemia was achieved in a dog with an insulinoma by treatment, using streptozotocin. Nephropathy, manifested as a renal tubular defect, and hepatopathy were associated with the administration…
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Effect of cyclosporine and aminophylline on streptozotocin-induced diabetes in rats.
Diabetes induced in rats by multiple low doses of streptozotocin is thought to mimic type 1 disease in man. We tested the effect of concomitant treatment with immunomodulator drugs in…
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Phase 2 trial of streptozotocin by continuous infusion for metastatic colorectal carcinoma.
Streptozotocin is a nitrosourea with minimal activity against colorectal carcinoma when given by bolus administration. Continuous infusion (CI) streptozotocin has been reportedly less toxic. Twenty-six patients with widely advanced colorectal…
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Evaluation of Chemotherapy With Streptozotocin Combined With 5-Fluorouracil and Adriamycin in Patients With Zollinger-Ellison Syndrome and Metastatic Non-Beta-Islet Cell Neoplasm
Patients with Zollinger-Ellison Syndrome suffer from ulcers of the upper gastrointestinal tract, higher than normal levels of gastric acid, and tumors of the pancreas known as non-beta islet cell tumors.…
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First International Randomized Trial in Locally Advanced and Metastatic Adrenocortical Carcinoma Treatment (FIRM-ACT) Etoposide, Doxorubicin, Cisplatin and Mitotane vs Streptozotocin and Mitotane
Background: - There is no medical consensus about the best treatment for advanced adrenocortical cancer (ACC) that cannot successfully be treated with surgery alone. - In 2003, the International Consensus…
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